～Publications～

・Protective role of protease-activated receptor-2 in anaphylaxis model mice. Maho Nakazawa, Ryota Tochinai, Wataru Fujii, Mao Komori, Tomohiro Yonezawa, Yasuyuki Momoi, Shingo Maeda*. PLOS ONE. In Press.

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・Diffusion MRI Fiber Tractography and Benzodiazepine SPECT Imaging for Assessing Neural Damage to the Language Centers in an Elderly Patient after Successful Reperfusion Therapy. Tatsushi Mutoh*, Yasuyuki Yoshida, Yasuko Tatewaki, Hongkun Chin, Ryota Tochinai, Junta Moroi, Tatsuya Ishikawa. Geriatrics. (2024) 9(2) 30.

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・Cardiopulmonary Events of the Elderly (≥75 Years) during Clazosentan Therapy after Subarachnoid Hemorrhage: A Retrospective Study from a Tertiary Stroke Center in Japan. Tatsushi Mutoh*, Hiroaki Aono, Wataru Seto, Takehiro Kimoto, Ryota Tochinai, Junta Moroi, Tatsuya Ishikawa. Medicina. 60(1):185. 2024.

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・Factors Influencing Discontinuation of Clazosentan Therapy in Elderly Patients with Aneurysmal Subarachnoid Hemorrhage: A Retrospective Study from a Japanese Single Center. Tatsushi Mutoh*, Hiroaki Aono, Wataru Seto, Takehiro Kimono, Ryota Tochinai, Junta Moroi, Tatsuya Ishikawa. Med Sci Monit. 30: e943303-1–e943303-7. 2024.

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・Simple procedure for assessing diffuse subarachnoid hemorrhage successfully created using filament perforation method in mice. Mutoh, Tatsushi*; Tochinai, Ryota; Aono, Hiroaki; Kuwahara, Masayoshi; Taki, Yasuyuki; Ishikawa, Tatsuya. Anim Models Exp Med. In Press.

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・Acute exercise in a hot environment increases heat shock protein 70 and peroxisome proliferator-activated receptor g coactivator 1a mRNA in Thoroughbred horse skeletal muscle. Yusaku Ebisuda, Kazutaka Mukai, Yuji Takahashi, Toshinobu Yoshida, Aoto Kawano, Tsubasa Matsuhashi, Hirofumi Miyata, Masayoshi Kuwahara, Hajime Ohmura. Frontiers in Veterinary Science 10: 1230212, 2023.

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・Polyoxazoline-Conjugated L-Asparaginase: An Antibody-Production-Free Therapeutic Agent for Acute Lymphoblastic Leukemia. Yamada, Taiga; Ishimaru, Marika; Shoji, Takuma; Tomiyasu, Hirotaka; Tochinai, Ryota; Taguchi, Kazuaki; Komatsu, Teruyuki*. ACS Appl Bio Mater. 6(12), 5789–5797, 2023.

　

・Ivabradine ameliorates cardiomyopathy progression in a Duchenne muscular dystrophy model rat. Ryota Tochinai†*, Koichi Kimura†, Takeru Saika†, Wataru Fujii, Hiroyuki Morita, Koki Nakanishi, Yoshiharu Tsuru, Shin-ichi Sekizawa, Keitaro Yamanouchi, and Masayoshi Kuwahara. Exp Anim. In Press.

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・Plasticity occurs in a specific phenotype of neurons in the nucleus tractus solitarius of dystrophin-gene mutated rats. Akitoshi Chikamoto, Ryota Tochinai, Shin-ichi Sekizawa*, Masayoshi Kuwahara. Eur. J. Neurosci. 1-16. 2023.

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・Behavior and heart rate variability after intranasal administration of oxytocin in Holstein steers. Masumi YOSHIDA, Kosuke MOMITA, Masayoshi  KUWAHARA, Etsuko KASUYA, Madoka SUTOH, Ken-ichi YAYOU*. J Vet Med Sci. 85(9): 956–963. 2023.

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・Mastication stimuli regulate the heartbeat rate through rhythmic regulation by the hypothalamic-autonomic system; molecular and telemetric studies in weaning-stage rats. Seonmi Lee, Ryota Tochinai, Akihito Yasuoka*, Toshitada Nagai, Yoshikazu Saito, Masayoshi Kuwahara, Keiko Abe, and Tomiko Asakura. Front Neurosci. 2023; 17: 1260655.

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・Poly(2-ethyl-2-oxazoline)-Conjugated Hemoglobins as a Red Blood Cell Substitute. Wataru Okamoto, Yuuki Hiwatashi, Tatsuhiro Kobayashi, Yoshitsugu Morita, Hiroto Onozawa, Masayuki Iwazaki, Mitsutomo Kohno, Hirotaka Tomiyasu, Ryota Tochinai, Radostina Georgieva, Hans Bäumler, and Teruyuki Komatsu*. ACS Appl Bio Mater. https://doi.org/10.1021/acsabm.3c00392.

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・Anti-tumor and Cardiotoxic Effects of Microtubule Polymerization Inhibitors:The Mechanisms and Management Strategies. Tochinai R.*, Nagashima Y., Sekizawa S., Kuwahara M. J Appl Toxicol. 44. 96-106. 2024.　　

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・Polyoxazoline-Conjugated Porcine Serum Albumin as an Artificial Plasma Expander for Dogs. W. Okamoto, T. Usui, M. Hasegawa, T. Kobayashi, J. Fujisawa, K. Taguchi, K. Matsumoto, M. Kohno, M. Iwazaki, S. Shimano, I. Nagao, H. Toyoda, N. Matsumura, H. Tomiyasu, R. Tochinai, T. Komatsu*. Sci. Rep. 2023,13, 9512.

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・Co-administration of JQ1, a bromodomain-containing protein 4 inhibitor, enhances the antitumor effect of combretastatin A4, a microtubule inhibitor, while attenuating its cardiotoxicity. Orihara H., Ma M., Nagashima Y., Tochinai R.*, Sekizawa S., Kato D., Shinada M., Aoki S., Fujita N., Nakagawa T., Tsuru Y., Tatewaki Y., Mutoh T., Taki Y., Nishimura R., Kuwahara M. Biomed Pharmacother. 163, 114353. 2023.

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・Pretreatment of Tadalafil attenuates cardiotoxicity induced by combretastatin A4 disodium phosphate in rats. Nagashima Y., Tochinai R.*, Sekizawa S., Kato D., Nakagawa T., Tsuru Y., Tatewaki Y., Mutoh T., Taki Y., Kuwahara M. J Toxicol Pathol. 36, 151-158, 2023.

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・Preliminary study of heart rate variability in Criollo horses for the elucidation of their neurophysiological characteristics of autonomic nerve function. Seki N., Tochinai R.*, Sekizawa S., Márquez M.A., Fukuda K., Ohmura H., Kuwahara M. J Equine Sci. 34, 55-59. 2023.

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・ 乳牛のケトーシス発症前後における伏臥頻度の解析. 高橋 友継, 真方 文絵, 猪熊 壽, 桑原 正貴. 日畜会報　93(3)：225-232、2022.

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・Favorable Effects of Virgin Coconut Oil on Neuronal Damage and Mortality after a Stroke Incidence in the Stroke-Prone Spontaneously Hypertensive Rat. Vitor R.J.S. II, Tochinai R., Sekizawa S., Kuwahara M*. Life, 12(11), 1857. 2022.

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・Direct Wiring of Liquid Metal on an Ultrasoft Substrate Using a Polyvinyl Alcohol Lift-off Method. Koki Murakami, Ryota Tochinai, Daiki Tachibana, Yuji Isano, Ryosuke Matsuda, Fumika Nakamura, Yuta Kurotaki, Yutaka Isoda, Monami Yamane, Yuya Sugita, Junji Fukuda, Kazuhide Ueno, Norihisa Miki, Ohmi Fuchiwaki and Hiroki Ota*. ACS Appl Mater Interfaces. 14(5), 7241–7251. 2022.

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・Effects of Supplementation with a Quebracho Tannin Product as an Alternative to Antibiotics on Growth Performance, Diarrhea, and Overall Health in Early-Weaned Piglets. Min Ma, James K. Chambers, Kazuyuki Uchida, Masanori Ikeda, Makiko Watanabe, Yuki Goda, Daisuke Yamanaka, Shin-Ichiro Takahashi, Masayoshi Kuwahara, and Junyou Li. Animals 11(11): 3316, 2021. 

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・Loss of Group II Metabotropic Glutamate Receptor Signaling Exacerbates Hypertension in Spontaneously Hypertensive Rats. Hsu J.C., Sekizawa S*., Tochinai R., Kuwahara M*. Life. 11 (7), 720.​ 2021.

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・Chronic stimulation of group II metabotropic glutamate receptors in the medulla oblongata attenuates hypertension development in spontaneously hypertensive rats. Julia Chu-Ning Hsu, Shin-ichi Sekizawa*, Ryota Tochinai, Masayoshi Kuwahara*. PLOS ONE. 16(5). e0251495. 2021.

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・Autonomic nervous activity in rats can be evaluated by blood photoplethysmography-derived pulse rate variability analysis. Ryota TOCHINAI, Shin-ichi SEKIZAWA, Hidetoshi KOBAYASHI, Masayoshi KUWAHARA*. Translat Regulat Sci. 3(1):17 - 21. 2021.

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・Heart rate variability in dairy cows with postpartum fever during night phase. Takahiro AOKI, Megumi ITOH, Akiko CHIBA, Masayoshi KUWAHARA, Hirofumi NOGAMI, Hiroshi ISHIZAKI, and Ken-Ichi YAYOU. PLoS ONE 15(11): e0242856, 2020.

・Radiocesium transfer rates among pigs fed haylage contaminated with low levels of cesium at two differentiation stages. Chunxiang Piao, Min Ma, James K. Chambers, Kazuyuki Uchida, Masanori Ikeda, Natsuko I. Kobayashi, Atsushi Hirose, Keitaro Tanoi, Masayoshi Kuwahara, Junyou Li. PLoS ONE 15(9): e0237977, 2020.

・Distillation remnants of shochu, a traditional Japanese liquor, improve pork meat quality by reducing stress. Yasuhisa Ano, Jun You Li, Takahiro Jomoto, Daiji Kurihara, Ryohei Nishimura, Hiroyuki Nakayama, Masayoshi Kuwahara. Food Chemistry 318, 126488, 2020.

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・Cardiac lesions in Duchenne muscular dystrophy model rats with out-of-frame Dmd gene mutation mediated by CRISPR/Cas9 system. Mao Miyamoto, Ryota Tochinai*, Shin-Ich Sekizawa, Takanori Shiga, Kazuyuki Uchida, Yoshiharu Tsuru, Masayoshi Kuwahara*. Journal of toxicologic pathology 33(4) 227 - 236. 2020.

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・Research topics in regulatory science: Developmental and reproductive toxicity of human pharmaceuticals. Shin-ichi SEKIZAWA*. Translational and Regulatory Sciences 2(2) 60 - 67. 2020.

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・Effects of environmental enrichment on autonomic nervous activity in NSY mice. Kentaro Kaneko, Akitoshi Chikamoto, Julia Chu-Ning Hsu, Ryota Tochinai, Shin-Ichi Sekizawa, Machiko Yamamoto, Masayoshi Kuwahara*. Experimental animals 69(2) 161 - 167. 2019.

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・Early attenuation of autonomic nervous function in senescence accelerated mouse-prone 8

(SAMP8). Akitoshi Chikamoto, Shin-Ichi Sekizawa, Ryota Tochinai, Masayoshi Kuwahara*. Experimental animals 68(4) 511 - 517. 2019.

・Overexpression of heart-specific small subunit of myosin light chain phosphatase results in

heart failure and conduction disturbance. Takuro Arimura, Antoine Muchir, Masayoshi Kuwahara, Sachio Morimoto, Taisuke Ishikawa, Cheng-Kun Du, Dong-Yun Zhan, Shu Nakao, Noboru Machida, Ryo Tanaka, Yoshihisa Yamane, Takeharu Hayashi, and Akinori Kimura. American Journal of Physiology Heart and Circulatory Physiology 314:H1192－H1202, 2018.

・Identification of an intra- and inter-specific tear protein signal in rodents. Mai Tsunoda, Kazunari Miyamichi, Ryo Eguchi, Yasuo Sakuma, Yoshihiro Yoshihara, Takefumi Kikusui, Masayoshi Kuwahara, and Kazushige Touhara. Current Biology 28: 1213-1223, 2018.

・Evaluation of heat stress response in crossbred dairy cows under tropical climate by analysis of heart rate variability. Chan Bun, Youki Watanabe, Yoshihisa Uenoyama, Naoko Inoue, Nahoko Ieda, Fuko Matsuda, Hiroko Tsukamura, Masayoshi Kuwahara, Kei-Ichiro Maeda, Satoshi Ohkura, Vutha Pheng. Journal of Veterinary Medical Science 80(1): 181-185, 2018.

・The essential role of phospho-T38 CPI-17 in the maintenance of physiological blood pressure

using genetically modified mice. Qunhui Yang, Wataru Fujii, Noriyuki Kaji, Shigeru Kakuta, Kodai Kada, Masayoshi Kuwahara, Hirokazu Tsubone, Hiroshi Ozaki, and Masatoshi Hori. FASEB J. 32: 2095–2109, 2018.

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・Histopathological and functional changes in a single-dose model of combretastatin A4 disodium phosphate-induced myocardial damage in rats. Ryota Tochinai*, Kayoko Komatsu, Junta Murakami, Yuriko Nagata, Minoru Ando, Chie Hata, Tomo Suzuki, Shoichi Kado, Toshihide Kobayashi, and Masayoshi Kuwahara. Journal of Toxicologic Pathology 31(4): 307–313. 2018.

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・Schizophrenia-like phenotypes in mice with NMDA receptor ablation in intralaminar thalamic

nucleus cells and gene therapy-based reversal in adults. Kosuke Yasuda, Yu Hayashi, Takamasa Yoshida, Mitsuaki Kashiwagi, Nao Nakagawa, Takayuki Michikawa, Mika Tanaka, Reiko Ando, Arthur Huang, Toshihiko Hosoya, Thomas J. McHugh, Masayoshi Kuwahara, and Shigeyoshi Itohara. Translational Psychiatry 7: e1047, 2017.

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・WTC rat has unique characteristics such as resistant to streptozotocin. Yoshiaki Nagaki, Koichi Ito, and Masayoshi Kuwahara. Biochemistry and Biophysics Reports 8: 157-161, 2016.

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・Combretastatin A4 disodium phosphate-induced myocardial injury. Ryota Tochinai*, Yuriko Nagata, Minoru Ando, Chie Hata, Tomo Suzuki, Naoyuki Asakawa, Kazuhiko Yoshizawa, Kazumi Uchida, Shoichi Kado, Toshihide Kobayashi, Kimiyuki Kaneko, and Masayoshi Kuwahara. Journal of Toxicologic Pathology 29:163-171, 2016.

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